Determining How Defects in Connexin 43 Cause Skeletal Diseases
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چکیده
iv ACKNOWLEDGMENTS I wish first to express my sincere appreciation to Dr. Kathy Iovine, my graduate mentor. Your advice, guidance, understanding and constant support have shaped my graduate career to success. Thank you so much for being with me when I thought I could have failed the program. Thank you for thinking ahead and helping me to find the solution for the problems. Your expectations and high standards ultimately helped me to improve and develop into a form of scientist I am today. I will miss working with you….will miss hours of making figures on photoshop….hours of writing manuscripts….hours of making presentations that later I know you would ask me to correct them all over again but I know in the end they would look/sound good, clean and pretty. To my mother and father, the first and forever teachers of my life. I have no words to describe how much I thank you for what you had sacrificed for me so that I could have a better life and better education. Dad, you were with me 24/7 taking care of my sickness when I was a little child. You taught me from how to make the first baby step to how to do math and later how to become a good person that carries a warm heart and dignity. Your lessons will always be with me…will help me continue to stand strong when I face challenges in life. Though you are no longer here with me, I know in the end we will meet and will together once again continue the daughter-father journey… Mom, your strict teaching helped me to become a strong and determined woman. I truly hope you will live long with us to see your first future grand-children…to help me teach them just like the way you did to me so that they can also become strong and independent. To my wonderful thesis committee members, without your critics and encouragements, I never would have accomplished this. To Dr. Poss, thank you so much for taking your time to give me valuable inputs. Thank you for pushing me forward, for making me to think harder in each scientific scenario. Your suggestions have helped me to see the v whole aspects of my research, to find the way to apply what I have learned to solve the problem. To professors and entire staff in the Biology Department, thank you …
منابع مشابه
Determining how defects in connexin43 cause skeletal disease.
Gap junction channels mediate direct cell-cell communication via the exchange of second messengers, ions, and metabolites from one cell to another. Mutations in several human connexin (cx) genes, the subunits of gap junction channels, disturb the development and function of multiple tissues/organs. In particular, appropriate function of Cx43 is required for skeletal development in all vertebrat...
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BACKGROUND Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy. The functionality of skeletal muscle cells in the heart milieu is, however, limited because of their inability to integrate electrically and mechanically in...
متن کاملOverexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal Title: myoblasts with cardiac myocytes in vitro Authors:
Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal Title: myoblasts with cardiac myocytes in vitro
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Sertoli cells are an essential group of cells in seminiferous epithelium which provide nutritional and structural supports for spermatogenic cells via cell junctions. In this study, the gene expression of connexin-43, the most abundantly distributed gap junction protein of cells, was investigated in ram Sertoli cells under mild and severe heat stresses with real-time quantitative PCR. Sertoli c...
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Dilated cardiomyopathies are common forms of primary myocardial disorders responsible for severe heart failure which may require cardiac transplantation. Viral infection, alcohol, carnitine deficiency or mutation within the dystrophin gene have been recognized as causative for the myopathy. Epidemiological studies have shown that approximately 20% of these cardiomyopathies are inherited. A subs...
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